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First published online December 30, 2003

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A different STATus quo in Dictyostelium

The interaction between SH2 domains and phosphotyrosine residues is central to many signalling pathways in metazoans, including those that involve STATs (signal transducers and activators of transcription). Dictyostelium is the only non-metazoan known to have functional SH2 domains and Zhukovskaya et al. now describe the SH2 domain protein Dd-STATb, the third known Dictyostelium STAT (see p. 447). Although the SH2 domain of Dd-STATb is highly divergent from other SH2 domains, Dd-STATb is biologically functional: Dd-STATb-null cells have a slight growth disadvantage when co-cultured with parental cells, and gene expression patterns are altered in Dd-STATb- cells when compared with Dd-STATb+ cells. Like other STATS, Dd-STATb exists as a homodimer. But, say the researchers, homodimerisation of Dd-STAT is unlikely to occur through the orthodox SH2 domain:phosphotyrosine interaction seen in animal STATs, and so may represent a non-canonical signalling mechanism not seen in animals.

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Dd-STATb, a Dictyostelium STAT protein with a highly aberrant SH2 domain, functions as a regulator of gene expression during growth and early development

Natasha V. Zhukovskaya,, Masashi Fukuzawa,, Masatsune Tsujioka, Keith A. Jermyn, Takefumi Kawata, Tomoaki Abe, Marketa Zvelebil, and Jeffrey G. Williams
Development 2004 131: 447-458. [Abstract] [Full Text]  

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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?