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Fig. 4. Range of pre-axial polydactylies observed in the hind limbs of 4C-BAC16
mutants. (A,C,E,G,I) Polydactylous limbs prior to skeletal
preparation/staining. (B,D,F,H,J) The corresponding skeletal structure after
staining with Alcian Blue and Alizarin Red. (A,B) Dorsal view of postnatal day
6 wild-type right hind limb, showing the biphalangeal nature of digit I (toe)
and triphalangeal nature of digits II-V. (C,D,F-J) Dorsal views of postnatal
day 7 mutant limbs; (E) ventral view. (C,D) Left hind limb; (E-J) right hind
limbs; C-F show limbs from the same animal. Note the triphalangeal nature of
mutant digit I in F,H,J. The most frequent form of polydactyly observed
(n=7/18) was that shown in F, and in seven out of eight bilateral
polydactylous limbs, this type of defect was accompanied by the type shown in
D. Note that there is no abnormality in shape, size, length or rate of
ossification of the remaining digits. Scale bars: 2 mm in B,D,F,H,I,J; 3 mm in
A,C,E,G,I.
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