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Fig. 2. Skeletal abnormalities in Tsg-/- mice. (A) Comparison
of 5-week-old wild-type and Tsg-/- mice. The
Tsg-/- mouse is small and displays a short tail with
multiple kinks. (B) X-ray of the caudal region of wild-type and
Tsg-/- adult mice. The tail vertebrae in the mutant are
shorter (compare tail vertebra 7, TV7) and have less X-ray opacity (inset).
(C-C') Alcian Blue preparations of E14.5 wild-type and
Tsg-/- embryos in lateral view. Note the defects in
cervical and thoracic neural arch cartilages in Tsg-/-
embryos. (D-D') Alcian Blue/Alizarin Red preparations of cervical
vertebrae of 2-week old wild-type and Tsg-/- mice. The
cervical neural arches are not fused dorsally in the mutant. (E-E')
Alcian Blue/Alizarin Red preparations of the caudal regions of wild-type and
Tsg-/- newborn mice. Note the presence of two centers of
ossification in the mutant rather than a single one in the wild-type. The
seventh tail vertebra is indicated. (F,F',G,G') Skeletal elements
of the tail of 2-week old wild-type and Tsg-/- mice
stained with Alcian Blue/Alizarin Red. (F') Abnormal vertebrae present a
bow-tie shape and are shorter than the wild-type (compare TV7). (G') One
ossification center has failed to form, producing hemi-vertebrae with
misaligned articular surfaces, which cause the kinks. at, atlas; ax, axis;
C3-7, cervical vertebrae 3-7; na, neural arch; T4, thoracic vertebra 4.
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