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Fig. 5. Holoprosencephaly in Tsg-/-;Bmp4+/-
embryos at E15.5. (A-A') E15.5 wild-type and
Tsg-/-;Bmp4+/- embryos. The plane of
sections shown below are designated b,b',c and c'.
(B,B',C,C') Histological sections were stained with Hematoxylin
and Eosin. The lateral ganglionic eminence (lge) is missing and the floor of
the diencephalon (fd) is greatly thickened in the mutant. Note the fusion of
the lateral ventricles, owing to the lack of a medial wall (mw) and the lack
of nasal septum (ns). In addition, note the empty orbits (ob), lack of lens
(ls) and retina (re) of the eyes. di, diencephalon; hy, hypothalamus; ll,
lower lid; lv, lateral ventricle; ol, olfactory epithelium; to, tongue; ul,
upper lid; vi, follicles of vibrissae; 3V, third ventricle.
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