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Fig. 7. Defective development of telencephalic vesicles and first pharyngeal arch in Tsg^-/-;Bmp4^+/- embryos. The phenotypes of Tsg^-/- and Bmp4^+/- were indistinguishable from wild-type. (A-A') Frontal view of E10.5 embryos stained with Dlx5. Insets show lateral views. The right mandibular component of the first arch is missing in the compound mutant (arrow). hy, hyoid arch; md, mandibular component of the first pharyngeal arch. (B,B',C,C') Lateral view of E8.5 and E8.25 embryos hybridized with Fgf8. (B) At E8.5 Fgf8 is expressed in the proximal ectoderm of the first pharyngeal arch (a1), isthmus (is), commissural plate (cp) and tailbud (tb). (B') Expression in the pharyngeal arch and the commissural plate (indicated by an asterisk) is missing in the mutant. (C-C') At E8.25, Fgf8 is present in the anterior neural ridge (anr), isthmus, pharyngeal endoderm (en) and tailbud; no differences in Fgf8 expression were observed at this stage. (D-D') At E8.5 Shh is expressed in the basal mesencephalon (bm), basal diencephalon (bd) and basal telencephalon (bt) and the notochord. Expression in the basal diencephalon and basal telencephalon is missing in the mutant (asterisk). (E-E'). Expression of mouse Cer1 in the anterior visceral endoderm (ave) of wild-type and Tsg^-/-;Bmp4^+/- embryos at E6.5. (F-F') Expression of Hex in the anterior endoderm (ae) and node (no) of wild-type and Tsg^-/-;Bmp4^+/- embryos at E7.5.

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