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Fig. 2. Structural analysis of Dd-STATb. (A) The C
trace of Dd-STATb (blue),
superimposed on STAT1 (magenta), was used as a template for modelling
Dd-STATb. The invariant arginine at position ßB5 is shown in red (in
STAT1) and its equivalent residue in Dd-STATb, a leucine, is shown in blue.
The two main inserts are highlighted. (B) Dd-STATb is superimposed on the Src
SH2 domain, with the arginine/leucine variation highlighted and the Src
phosphopeptide also shown. (C) A ribbon diagram of Dd-STATb (in blue)
superimposed on the whole structure of STAT1, showing that the position of the
large insert (insert1) would not disrupt a similar dimerisation as that seen
for STAT1. (D) The C trace for Dd-STATb (red), STAT1 (blue) and STAT3
(green). The phosphorylated Serine residues are shown in STAT1 and STAT3. It
is apparent that the positions of insert 1 and insert 2 are regions of
dissimilarity in both STAT1 and STAT3.
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