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First published online September 30, 2004

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Building an adult insect nervous system

Insects that undergo complete metamorphosis, such as Drosophila, have two waves of neurogenesis. The embryonic wave, which generates the neurons that regulate larval behaviour, has been extensively studied. However, little is known about the postembryonic patterning of the adult-specific structures of the central nervous system (CNS). On p. 5167, Truman and colleagues use mosaic analysis with a repressible cell marker (MARCM) to follow adult-specific lineages of cells produced from individual neuroblasts in the ventral CNS of larval Drosophila. They identify the 24 lineages that make up the scaffold of a thoracic hemineuromere, and show that the adult-specific cells in a given lineage are all very similar and project to only one or two initial targets. The description of these initial contacts provides a developmental framework for future studies into how the complex connectivity of the adult CNS is achieved.

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Related articles in Development:

Developmental architecture of adult-specific lineages in the ventral CNS of Drosophila

James W. Truman, Hansjürgen Schuppe, David Shepherd, and Darren W. Williams
Development 2004 131: 5167-5184. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?