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Fig. 1. Wing size correlates with Dpp activity. (A-D) Wing discs containing
different levels of Dpp activity in the wing pouch. All the discs are doubly
stained for wg and GFP. All discs are presented at the same
magnification, as indicated by the band of wg expression (red) in the
thoracic region, which is not modified in the genotypes used. The wing pouch
is labelled green using the UAS-GFP construct, which is not shown in
the figure for simplification, with the nub-Gal4 driver. (A) The
amount of Dpp signal is twice that in B, and results in a larger disc. (C)
nub-Gal4>UAS-GFP disc contains a normal amount of Dpp. (D) The
elevated levels of dad antagonise Dpp activity and produce a very
small wing pouch. (E) Wing disc of the same genotype as in B, showing BrdU
incorporation concentrated in the lateral region. (F-I) Adult wing size is
dependent on the activity levels of the Dpp pathway: the greater the activity,
the larger the wing.
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