|
|
|
|
|
|
|
||||
| Home Help Feedback Subscriptions Archive Search Table of Contents | ||||
|
Fig. 1. Ontogeny of p63 in urogenital sinus (UGS) and phenotype of
p63–/– UGS. (A-D) Ontogeny of p63 in embryonic
UGS. CA, cloaca; HG, hind gut; MND, mesonephric duct; NT, neural tube. Cross
section (A) and saggital section (B-D) of mouse embryos. Scale bar: 50 µm.
(E-O) Marker expression was examined in male p63+/+ UGS
(E-H,M) and male (I-L,N) and female (O) p63–/–
UGSs at E17.5. MD, Müllerian duct; WD, Wolffian duct. Gross morphology of
the p63–/– UGS was normal and showed normal
sexual dimorphism at E17.5 (compare O [female] with I-L [male]).
p63–/– urogenital sinus epithelium (UGE)
expressed differentiation markers identical to that of
p63+/+ UGE [uroplakin (G,K), involucrin (H,L) and androgen
receptor (AR) (M,N)] with the exception that p63 (E,I) and K14 (F,J) were
absent in p63–/– UGE. In both male
p63+/+ and p63–/– UGSs,
notice epithelial outgrowths into stroma in the area where prostates normally
form (black and white arrows).
|
