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Fig. 9. Schematic diagram hypothesizing a dual function of reelin in the dentate
gyrus. (A) Reelin (blue), synthesized by Cajal-Retzius cells (dark blue) in
the marginal zone (m) provides a positional signal for radial glial fibers
(green, arrow). The glial cell bodies are located in the secondary
proliferation zone, the future hilus (h). (B) Glial cell processes have
reached the pial surface, providing a scaffold for the migration of neurons
(red). (C) Reelin provides a stop signal for migrating granule cells.
Following migration, granule cells accumulate in a layer directly underneath
the marginal zone. Alternatively, some radial glial cells may retract their
long hilar process (soma translocation), thereby accumulating directly
underneath the granular layer (right radial glial cell). Here they may divide
and become neurons, inheriting the radial glial apical processes
(Miyata et al., 2001).
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