spacer gif spacer gif spacer gif spacer gif spacer gif
QUICK SEARCH:   [advanced]


spacer gif
     Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents    

Right arrow Help viewing high resolution images
Right arrow Return to article
(Downloading may take up to 30 seconds.
If the slide opens in your browser, select File -> Save As to save it.)
Click on image to view larger version.



Fig. 3. Mast cells degranulate in TrkA-deficient mice. Histological assessment of passive cutaneous anaphylaxis in control (A,C,E) and TrkA mutant (B,D,F) mouse ear sections stained for naphthol AS-D chloroacetate esterase. Compared with saline challenged mice (A,B), the IgE/DNP-treated mice (C-F) exhibited prominent mast cell degranulation and mixed inflammatory cell infiltrates. Arrows are directed to degranulated mast cells. (G) ß-hexoseaminidase release from bone marrow-derived mast cells obtained from TrkA mutant (TrkAneo/neo) and control (TrkA+/+) littermate mice was measured as described in Materials and methods. Mast cells obtained from the TrkA mutant mice show reduced ß-hexoseaminidase release relative to those from controls (*P<0.01).





Right arrow Return to article