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Fig. 4. TrkA deficiency in the immune system causes increased Ig production. (A)
T
1-Cre;TrkAneo/neo mice have increased levels of
specific classes of Igs. IgM, IgG2a, IgG2b, IgG1 and IgG3 serum levels were
measured by ELISA in 12-16-week-old mutants (KO, n=18) and control
littermates (CTR, n=14). Data are expressed in Units/ml where 1 U=1
mg for IgM and 1 U=1 µg for IgG2a, IgG2b, IgG1 and IgG3. Bars:
means±s.e.m. Data were evaluated using a two-tailed Student's
t-test. *P<0.05. (B) C57Bl/6-SCID mice
reconstituted with TrkA-deficient fetal liver cells (KO, n=10) have
increased levels of serum Igs compared with TrkA wild-type-reconstituted
controls (WT, n=6). C57Bl/6-SCID mice were reconstituted and
monitored for Ig serum levels from 1 to 5 months after reconstitution. Data
after two months from reconstitution are shown. All Ig classes are higher in
TrkA-deficient animals, although only IgM and IgG2b are statistically
different from controls (two-tailed Student's t-test.
*P<0.05).
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