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Fig. 5. Absence of TrkA does not impair T-cell-dependent memory nor
T-cell-independent type I and II B responses. (A) For the TD memory response,
T
1-Cre;TrkAneo/neo (n=7) and control
littermates (n=6) were immunized with KLH-TNP as described in
Materials and methods. (B,C) for the TI type I and II responses, mice were
immunized respectively with LPS-TNP (B, six mutants and five controls) or
Ficoll-TNP (C, six mutants and seven controls). Serum levels of specific
anti-TNP Igs were measured by ELISA before immunization (0), at one (1) and
two (2) weeks after the challenge. Bars: means±s.e.m. Data were
evaluated using a two-tailed Student's t-test.
*P<0.05.
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