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Fig. 6. Nkx6 promotes axon growth and guidance of RP1,3,4,5 MNs. Confocal projections of four micron series from dissected stage 16 (A) wild-type and (B-D) Nkx6^D25 nerve cords carrying a lim3-tmyc transgene. -Myc marks axon projections of RP1,3,4,5. (A-D) An asterisk indicates the RP MN cell bodies and arrowheads mark the extent of the RP axon projection. (A) In wild type, RP motor axons leave the CNS. Nkx6^D25 mutant embryos RP motor axons display various defects. (B) RP motor axons frequently truncate and exhibit aberrant morphology. (C) RP motor axons in the bottom left and both right hemisegments are markedly thinner than in wild-type embryos. (D) RP motor axons in the top left hemisegment diverge from their normal course and turn toward the midline. (E,F) Confocal projections of four micron series from dissected stage 16 nerve cords from (E) wild-type and (F) Nkx6^D25 mutant embryos labeled with Fas3. (E) In wild type, the Nkx6-positive RP MNs express Fas3 (arrowheads) as do Nkx6-negative lateral neurons (arrows). (F) In Nkx6 mutant embryos, RP MNs lose Fas3 expression (arrowheads), while expression in more lateral Nkx6-negative neurons is unaffected (arrows). Anterior is up in all panels.

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