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Fig. 4. Loss of Par-6 results in disorganized border cell clusters and a misdistribution of E-cadherin and ßps-integrin. (A-B) Confocal sections of wild-type migrating border cell clusters stained with anti-Singed antibody. (C-E) Morphology changes due to activation of two copies of the RNAi par-6 transgene in the border cells and the two central polar cells, using slbo-Gal4, expressed in the border cells, and upd-Gal4, expressed in the polar cells. Arrows show lamellipodia and long processes in cells depleted of Par-6. (F) E-cadherin protein expression in a wild-type border cell cluster. Border cell/border cell and border cell/polar cell boundaries express higher levels of E-cadherin than border cell/nurse cell junctions which are indicated by arrowheads. (G) Border cells depleted of Par-6. E-cadherin levels are high throughout the cluster. ßps-integrin expression is disrupted in Par-6 depleted (I) versus wild-type cells (H).





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