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Fig. 1. Mutation of the gene that encodes the ß{nu} integrin subunit. (A) ß{nu} genomic region. The transposon insertion EP(2)2030 was used to create imprecise excisions that partially delete the ß{nu} locus. The ß{nu}1 deletion removes the first 69 amino acid codons while ß{nu}2 removes the first eight and ~2 kb upstream regulatory sequence. Neither allele affects surrounding genes. (B) In situ hybridization against ß{nu} transcripts in wild-type and ß{nu}2 embryos demonstrates that ß{nu}2 mutants do not make any detectable transcript. (C) Adult flies homozygous for ß{nu}1 and ß{nu}2 are viable, and have no obvious morphological defects.





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