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Fig. 4. Midgut migration is entirely dependent on integrins. Wild-type and mutant
embryos were stained with anti-filamin 1 (Cheerio) antibodies to mark the
migrating midgut endoderm (A'-H' and magenta in A-H) and
anti-Fasciclin 3 antibodies to label the visceral mesoderm palisade (green in
A-H) upon which the midgut cells migrate. Genotypes are labelled above and
stages are indicated on the left. All mutant embryos lack both the maternal
and zygotic contributions of the indicated gene products. (A,B) While the
midgut primordia have nearly met in the centre of stage 12 wild-type embryos,
migration is delayed in embryos lacking ßPS. (F) ßPS-
mutant embryos eventually recover and midgut migration is complete by stage
13. (G) Embryos lacking ßPS and ß
do not recover, however, and
midgut migration is completely blocked. (D) Midgut migration is delayed in
embryos lacking talin but, like ßPS- mutants, migration is
complete by stage 13 (H).
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