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Fig. 8. Integrins are not required for other migration events. (A,B) Embryos were stained for the Vasa protein, which labels the migrating primordial germ cells (green). The mesoderm surrounding the germ cells was labelled with antibodies against talin (magenta). (A) Wild-type germ cells have migrated to their final position near the posterior of the embryo and have nearly coalesced at late stage 13. (B) Germ cells migrate properly and coalesce in embryos that lack the maternal and zygotic contributions of both ß subunits despite defects in germ-band retraction. (C) Migration of the border cells. Clones of cells lacking ßPS were generated by mitotic recombination in ß{nu}2 homozygous larvae. A recombination event yields two cells: one homozygous mutant and one homozygous wild type, which is marked with GFP. ßPS-;ß{nu}2 mutant border cells (lacking GFP, broken outline) do not lag behind or otherwise stray from wild-type border cells (GFP positive). Filamentous actin is shown in magenta, GFP in green.





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