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Fig. 3. The CNS and the NMJ are normal in acc. (A) Schematic summary of
the experimental procedure. Embryos (48 hpf) are pinned on a dish through the
notochord. The skin is peeled off to allow access to the muscle cells. Muscle
voltage responses are evoked by mechanosensory stimulation delivered by a puff
of water and are measured with a patch electrode. Wild-type siblings (B) and
acc (D) display similar rhythmic depolarizations (fictive swimming),
whereas strychnine-treated wild-type siblings (C) respond with a non-rhythmic,
shorter depolarization.
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