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Fig. 10. Osteoporosis in rs/rs adult mice. (A-F) X-ray radiography (A,B)
and histology (C-F) of the lumbo-sacral vertebrae were carried out in
rs/rs (B,D,F) and control (A,C,E) animals. The boxed areas in C and D
are shown at a higher magnification in E and F, respectively. The arrowhead in
F points to a group of chondrocytes inside the trabecule. Scale bars: 50
µm. (G-I) Low bone mass phenotype in rs mutants demonstrated by
pQCT. Bone density and the thickness of cortical bones in the metaphysis of
the tibia were measured in rs/rs, rs/+ and +/+ animals (14 month-old
females in triplicate for each genotype), and results are graphically depicted
for bone density measures from total tibial metaphysis (G) and the cortex part
(H), and for the cortical bone thickness (I). Values represent the means +
standard errors. Single and double asterisks indicate statistically
significant reductions (P<0.05 and P<0.01,
respectively) in rs/rs compared with +/+.
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