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First published online October 27, 2004

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Sending Notch signals from different compartments

The Notch signalling pathway is an evolutionary conserved mechanism that regulates many cell-fate decisions. In the canonical pathway, the binding of ligands to Notch at the cell surface activates this transmembrane protein by releasing an intracellular domain from it, which translocates to the nucleus where it acts as a co-activator for the DNA-binding protein Suppressor of Hairless, Su(H). Hori and colleagues now describe how Deltex (Dx) – a Drosophila E3 ubiquitin ligase – positively regulates Notch signalling in the wing imaginal disc in a Su(H)-independent manner (see p. 5527). By examining a series of fly mutants, the researchers show that Notch movement from the cell surface to the late endosome requires Dx, and that this translocation is essential for Dx-mediated activation of Su(H)-independent Notch signalling. Thus, they conclude, two distinct signalling pathways downstream of a single receptor are uniquely activated in different membrane-bound compartments.

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Related articles in Development:

Drosophila Deltex mediates Suppressor of Hairless-independent and late-endosomal activation of Notch signaling

Kazuya Hori, Maggy Fostier, Mikiko Ito, Takashi J. Fuwa, Masahiro J. Go, Hideyuki Okano, Martin Baron, and Kenji Matsuno
Development 2004 131: 5527-5537. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?