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First published online October 27, 2004

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Crucial timing in brain building

The size, shape and structural integrity of the nervous system (and of other organs) depend on how many times its stem cells divide before differentiating. On p. 5539, Hatakeyama et al. report that the Hes genes, effectors of the Notch signalling pathway, control the timing of neural stem cell differentiation in the mouse nervous system. In normal mice, both neuroepithelial cells and the radial glial cells that are derived from them are neural stem cells; that is, they initially self-renew before undergoing terminal differentiation. In the absence of Hes1, Hes3 and Hes5, the researchers show that neuroepithelial cells form normally but are not properly maintained, and that radial glial cells prematurely differentiate into neurons. The resultant disorganisation of the nervous system in these mice, suggest the researchers, is because the missing radial glial cells normally form the structures that maintain neural tube morphology.

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Related articles in Development:

Hes genes regulate size, shape and histogenesis of the nervous system by control of the timing of neural stem cell differentiation

Jun Hatakeyama, Yasumasa Bessho, Kazuo Katoh, Shigeo Ookawara, Makio Fujioka, François Guillemot, and Ryoichiro Kageyama
Development 2004 131: 5539-5550. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?