QUICK SEARCH:   [advanced] Author: Keyword(s):
Home     Help     Feedback     Subscriptions     Archive     Search     Table of Contents

First published online October 27, 2004

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?

Recovering from apoptosis

Unlike many developmental processes, wing imaginal disc development in Drosophila does not normally involve apoptosis. Irradiation of the disc, however, induces apoptosis in 60% of the cells, but, surprisingly, the resultant adult fly has normal wings. On p. 5591, Pérez-Garijo and colleagues report that the expression of Wg and Dpp – two important signalling molecules in fly development – may contribute to the mechanism that normally compensates for cell loss after irradiation. They produced wing aberrations by inducing apoptosis in the imaginal disc and then inhibiting cell death with a caspase inhibitor. These perturbations caused excess proliferation in and modifications to the wing disc's normal compartment boundaries, and the permanent misexpression of wg and dpp. Because the resulting cell changes resemble those seen in vertebrate tumour cells, the researchers speculate that tumorigenesis could partly result from the uncoupling of apoptosis initiation and cell death.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

Related articles in Development:

Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila

Ainhoa Pérez-Garijo, Francisco A. Martín, and Ginés Morata
Development 2004 131: 5591-5598. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?