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First published online October 27, 2004

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Neural crest stem cells: new contributions to the PNS

Neural crest stem cells (NCSCs), which persist in peripheral nerves throughout late gestation, are generally thought to give rise only to Schwann cells. However, Joseph and co-workers now report that NCSCs generate not only Schwann cells but also endoneurial fibroblasts in developing mouse peripheral nerves (see p. 5599). By using Crerecombinase fate mapping, the researchers show that only these cell types, and not the others present in peripheral nerves, are neural crest derived. Other results indicate that neuregulin, Notch ligands and bone morphogenetic proteins may be involved in this multilineage differentiation of NCSCs. The researchers conclude that nerve development is more complex than previously thought, involving NCSC self-renewal, lineage commitment and multilineage differentiation. They also propose that neurofibromas, which often contain both fibroblasts and cells that resemble Schwann cells, may arise from transformation of NCSCs.

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Neural crest stem cells undergo multilineage differentiation in developing peripheral nerves to generate endoneurial fibroblasts in addition to Schwann cells

Nancy M. Joseph, Yoh-suke Mukouyama, Jack T. Mosher, Martine Jaegle, Steven A. Crone, Emma-Louise Dormand, Kuo-Fen Lee, Dies Meijer, David J. Anderson, and Sean J. Morrison
Development 2004 131: 5599-5612. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?