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Fig. 6. Sensory nerve defects in Y1227F knock-in mutants. Homozygous E12.5 knock-in embryos were subjected to whole-mount immunostaining using anti-neurofilament antibodies. The morphologic appearance of the sensory cutaneous nerves in the thoracic cavity wall region is shown for (A) Erbb2wt/wt (B) Erbb2Y1028F/Y1028F (C) Erbb2Y1144F/Y1144F and (D) Erbb2Y1227F/Y1227F. Note that the nerves in D are disorganized and defasciculated.





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