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Fig. 6. The cerebellum in Shh-P1 mice overgrows after P5. Midsagittal
sections of WT and mutant brains at P5 appear morphologically similar (A,E).
By P8, the mutant IGL (indicated by bars) begins to appear thicker (B,F). At
P14, the mutant IGL is noticeably thicker (G) compared with WT (C). The
phenotype is most apparent at P28 when the IGL is also irregularly shaped
(arrowheads in H), particularly around the primary fissure (arrows). [Note:
Fig. 6D,H are duplicated from Fig.
5B,F and placed here for comparison to other stages.] Scale bar:
350 µm in A,E; 500 µm in B,C,F,G; 400 µm in D,H.
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