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Fig. 9. Model of peripheral nerve development. NCSCs self-renew in peripheral
nerves to generate additional NCSCs
(Morrison et al., 1999), as
well as undergoing restriction under the influence of Nrg1, Delta and Bmp4.
The resulting restricted progenitors lack neuronal potential (non-neuronal)
but undergo lineage commitment to form both glial and myofibroblast
progenitors. Glial progenitors differentiate to form both myelinating and
non-myelinating Schwann cells, and myofibroblast progenitors differentiate to
form endoneurial fibroblasts. It is likely that Nrg1, Delta and Bmp4 play
multiple roles by having different effects on different cells within these
lineages. For example, Nrg1 promotes the survival and glial restriction of
NCSCs (Morrison et al., 1999;
Shah et al., 1994), whereas it
promotes the survival, proliferation and maturation of glial
progenitors/Schwann cells (Dong et al.,
1995), and the proliferation but not the survival of myofibroblast
progenitors (Morrison et al.,
1999).
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