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Fig. 5. LATE requires the activity of Pax6 in the mouse. (A) Schematic of the expression domain of Pax6 in the telencephalon of the mouse [reproduced, with permission, from Stoykova et al. (Stoykova et al., 2000)]. (B) Control embryo carrying the –3.1ngn1:nlacZ transgene. (C) Pax6sey/sey embryo carrying the –3.1ngn1:nlacZ transgene, showing the loss of reporter expression, indicating that LATE activity depends on Pax6. Coronal sections through the telencephalon with dorsal up. (D,E) Lateral view of the two zebrafish pax genes, pax6.1 (D) and pax6.2 (E) shows overlapping expression in the fore- and hindbrain (insets). Staining is detected mainly in the dorsal diencephalon, reminiscent of the –3.1ngn1:gfp transgene (see Fig. 4A). m, mantle zone; v, ventricular zone.





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