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Fig. 4. Noggin induces ectopic Fgf8 expression throughout the depth of the
cortical neuroepithelium. (A) E10.5 forebrain viewed from the dorsal side.
Noggin misexpression has induced a patch of ectopic Fgf8 (arrowhead).
In addition, the normal domain of Fgf8 expression (asterisk) is
expanded along the two sides of the dorsal midline. (B) Coronal section
through a different cortical hemisphere, processed in the same way.
Fgf8 expression is evident at the midline (arrowhead) posterior to
its normal limit. A patch of ectopic expression extends further laterally,
filling the width of the neuroepithelium. (C) A higher magnification of
Fgf8 expression in B. Typical of dividing neuroepithelial cells,
labeled cell bodies lie near both the pial and ventricular surfaces (arrows in
C) and show polarized processes. Scale bar: 0.35 mm for A; 0.1 mm for B; 0.03
mm for C.
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