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Fig. 2. BMP inhibition is not sufficient for neural induction. Inhibition of BMP by misexpression of dnBMPR (A,B), Chordin (C,D), Noggin (G) or dnBMPR+Chordin+Noggin+Smad6 (E,F) is not sufficient to induce Sox2. (H,I) Sections through the embryos in F,G at the levels indicated. All cell pellets produce background staining after Sox2 in situ hybridization (E-I); sections are therefore necessary to show absence of expression in the epiblast.





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