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Fig. 4. BMP inhibition does not induce neural tissue even in combination with FGF8 and/or Wnt antagonists. Neither a source of FGF8 protein (A) nor inhibition of Wnt signalling by NFz8+Dkk+ Crescent ({alpha}Wnt; pellet of transfected cells) (B,D) induces Sox2 expression in competent area opaca epiblast. The same is seen after misexpression of a combination of FGF8+NFz8+Dkk+Crescent (C,E), FGF8+Smad6 (F,H,I), or of all of these together (FGF8+NFz8+Dkk+Crescent+Cerberus+Smad6) (G,J,K). The histological sections (D-G) show that the epiblast in direct apposition to the source of factors does not express Sox2.





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