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Fig. 2. Impaired chondrocyte differentiation and matrix deposition in vivo. (A) In
vivo BrdU labeling of E19.0 embryos. The labeling index (BrdU positive
cells/total cells) in zones of proliferating chondrocytes is shown. Bars
represent mean value±s.d.; n=2;
*P<0.001. (B) Ki67-positive cells in zones of
proliferating chondrocytes at E14.5, E16.5 and E18.5. (C) Von Kossa staining
of calcified matrix of E15.5 and E17.5
Fosl2–/– embryos and littermate controls.
Arrowheads indicate stained matrix in the zones of hypertrophic chondrocytes.
Pictures were taken at 50x magnification.
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