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Fig. 5. Growth retardation in coll2a1-Cre, Fosl2f/f mice. (A) X-ray analysis of a 23-day-old coll2a1-Cre, Fosl2f/f mouse and littermate control (arrowhead indicates kyphosis). (B) Decreased body size and body weight of coll2a1-Cre, Fosl2f/f mice at P10. Bars represent mean value±s.d.; n=5; *P<0.05. (C) PCR for Fosl2 deletion in tissues and organs of a 6-day-old coll2a1-Cre, Fosl2f/f mouse. The same deletion efficiency was observed in older mice. he, heart; li, liver; lu, lung; ki, kidney; sp, spleen; br, brain; th, thymus; ln, lymph node; mu, muscle; sk, skin; st, stomach; in, intestine; bm, bone marrow; sm, sternum; cv, calvariae.





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