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First published online November 11, 2004

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Pre-implantation development: Wnt signalling independent?

Many components of the developmentally important Wnt/ß-catenin signalling pathway are expressed in mouse pre-implantation embryos. However, on p. 5817, Kemler and colleagues report that this pathway does not regulate pre-implantation development. Furthermore, the control of ß-catenin levels in pre-implantation embryos and in some cells of post-implantation embryos does not involve the normal ß-catenin degradation pathway. The researchers use a Cre-loxP strategy to derive embryos expressing ß-catenin that lack the signals needed for its degradation. The pre-implantation development of these embryos is normal and the stabilised ß-catenin fails to travel to the nucleus to activate Wnt target genes. The extra-embryonic region of post-implantation embryos also develops normally, but embryonic endoderm cells prematurely express Wnt target genes and undergo a premature epithelial-mesenchymal transition. Future work will determine how pre-implantation and extra-embryonic cells, but not those of the post-implantation embryo, control the Wnt/ß-catenin signalling pathway.

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Stabilization of ß-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast

Rolf Kemler, Andreas Hierholzer, Benoît Kanzler, Stefan Kuppig, Kati Hansen, Makoto M. Taketo, Wilhelmine N. de Vries, Barbara B. Knowles, and Davor Solter
Development 2004 131: 5817-5824. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?