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First published online November 11, 2004

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Make no bones

Most of our bones are produced by endochondral ossification, the replacement of cartilage by bone. The individual steps of this process – chondrocyte proliferation followed by apoptosis, remodelling of the cartilage extracellular matrix (ECM), angiogenesis and osteoblast recruitment – are well characterised. Now Stickens and co-workers identify ECM remodelling as the dominant rate-limiting process in bone morphogenesis by examining how disruption of ECM remodelling affects bone development in mice (see p. 5883). They report that inactivation of Mmp13, which encodes collagenase 3, causes abnormal skeletal growth plate development. They also use mice lacking both Mmp13 and Mmp9 to show that these enzymes synergistically degrade collagen type II and aggrecan during bone development. These and other results lead the researchers to conclude that proper endochondral ossification requires not only the assembly of cartilage collagens but also their degradation.

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Related articles in Development:

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice

Dominique Stickens, Danielle J. Behonick, Nathalie Ortega, Babette Heyer, Bettina Hartenstein, Ying Yu, Amanda J. Fosang, Marina Schorpp-Kistner, Peter Angel, and Zena Werb
Development 2004 131: 5883-5895. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?