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First published online November 11, 2004

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Locating bicoid: step by step

Par-1, a Ser/Thr kinase, is required for cell polarisation in many organisms. In Drosophila oogenesis, for example, Par-1 is involved in several polarisation events, including the localisation of the anterior determinant bicoid mRNA. Riechmann and Ephrussi now report that Par-1 regulates the localisation of bicoid mRNA by phosphorylating Exuperantia (Exu; see p. 5897). They identify Exu, a mediator of bicoid mRNA localisation, as a phosphorylation target of Par-1 in a genome-wide, gel-based screen and describe two motifs in Exu that are phosphorylated by Par-1. Mutation of these motifs abolishes bicoid mRNA localisation in mid-oogenesis, but a proportion of the oocytes subsequently recover from these bicoid mRNA localisation defects, indicating that the requirement for Exu phosphorylation becomes less stringent as oogenesis proceeds. Finally, the researchers propose a multi-step model for bicoid mRNA localisation in which redundant mechanisms ensure its anterior accumulation.

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Par-1 regulates bicoid mRNA localisation by phosphorylating Exuperantia

Veit Riechmann and Anne Ephrussi
Development 2004 131: 5897-5907. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?