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First published online November 11, 2004

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Masterblind insights into CNS patterning

The Wnt signalling pathway controls anteroposterior (AP) patterning in the dorsal CNS of many species. Now Kapsimali and colleagues report that, in zebrafish, Wnt signalling also influences the AP identity of ventral CNS midline tissue (see p. 5923). Ventral midline cells form floorplate throughout the CNS, except in the anterior forebrain where they form the hypothalamus. The researchers show that masterblind zebrafish embryos, which lack functional Axin1 (an intracellular inhibitor of Wnt pathway activation), have more prospective floorplate and less prospective hypothalamic tissue than normal embryos. They also show that axin1 overexpression in normal prospective floorplate induces hypothalamic gene expression. The researchers suggest that Axin1 might modulate the response of ventral CNS cells to signals, such as Nodal, that induce ventral CNS identity and thus help to integrate dorsoventral and AP patterning information in the developing CNS.

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Related articles in Development:

Inhibition of Wnt/Axin/ß-catenin pathway activity promotes ventral CNS midline tissue to adopt hypothalamic rather than floorplate identity

Marika Kapsimali, Luca Caneparo, Corinne Houart, and Stephen W. Wilson
Development 2004 131: 5923-5933. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?