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Fig. 2. Categories of gene expression patterns that are associated with paraxial
mesoderm segmentation and maturation in the chick embryo. (A-E) In situ
hybridization gene expression patterns in the presomitic mesoderm (PSM). (A)
Genes that regulate the wavefront progression: the caudal-to-rostral
Fgf8 (fibroblast growth factor 8) gradient (left) and the
rostral-to-caudal Raldh2 (retinaldehyde dehydrogenase 2) gradient
(right). (B) Expression of a cyclic gene, chick Hairy1, in three
different phases that identify the segmentation clock. (C) Striped expression
of genes involved in segment specification and rostrocaudal
compartmentalization, such as these belonging to the
Mesp/Meso2/Thylacine1 bHLH transcription factor family. (D)
Expression pattern of paraxis (Tcf15), which is involved in the
epithelialization process during somite formation, in the anterior PSM and
somites. (E) Genes highlighting the rostrocaudal compartmentalization of the
formed somites, such as Uncx4.1, a paired homeobox transcription
factor that has restricted expression in the caudal part of the somites.
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