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Fig. 2. Expression of the stabilized form of ß-catenin leads to an ectodermal
phenotype. (A,B) Histological sections of E6.5 wild-type and mutant embryos
that were Hematoxylin and Eosin-stained. (C,D) Immunohistochemical analysis of
sections from E5.5 embryos to detect ß-catenin. (E,F) Immunohistochemical
analysis of sections from E6.5 embryos to detect ß-catenin.
ß-catenin was localized at the cell membrane in wild-type embryos,
whereas in the mutant epiblast, ß-catenin was enhanced and distributed
throughout the cells. All embryos are oriented with the embryonic part to the
left. EE, embryonic ectoderm. Arrow indicates thickened visceral endoderm in
the mutant. Scale bar: 100 µm.
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