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Fig. 3. Nuclear function of ß-catenin in mutant epiblast. Males of the
Wnt-reporter line, BAT-gal, were crossed to wild-type or
ß-catEx3flox/ß-catEx3flox;cre/+ females to obtain embryos
at E5.5 (A,B), E6.5 (C,D), and E7.5 (E,F). In wild type,
ß-galactosidase-positive cells can first be detected on the posterior
side of the proximal epiblast at E6.5 (C, arrow), and at E7.5 the
ß-galactosidase expression domain extended throughout the posterior part
of the embryo (E) (Maretto et al.,
2003). In contrast, in mutant embryos,
ß-galactosidase-positive cells were first found scattered throughout the
epiblast at E5.5, and this positive staining became enhanced at E6.5 and E7.5,
with no obvious pattern to the staining. Arrow: ß-galactosidase-positive
cells in wild-type E6.5 embryos.
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