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Fig. 3. Histological examination of the Mmp13–/–
trabecular bone defect. (A,B) Picrosirius Red stained tibia from 1-week-old
mice show no apparent increase in trabecular bone (TB) in
Mmp13–/– mice compared with wild type, but the
bone spicules in Mmp13–/– mice are irregular
in shape (indicated by arrow). At 3 weeks of age,
Mmp13–/– mice show increased trabecular bone
(C,D). Unlike the increase of hypertrophic cartilage (HC), which resolves at 5
weeks of age, the increase in trabecular bone in
Mmp13–/– mice persists for months (E,F).
Similar increases in trabecular bone can also be observed in femurs (G,H).
Histological observations were confirmed by Micro-CT analyses on tibia of
16-week-old wild-type and Mmp13–/– mice (I,J).
SO, secondary site of ossification. Scale bars: 200 µm in A,B; 300 µm in
C,D; 400 µm in E-H; 1 mm in I,J.
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