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Fig. 6. Phenotype of MMP13fl/fl;Col1-Cre+/– endochondral bones. (A,B) Safranin-O stained metatarsals from 3-week-old wild-type and MMP13fl/fl;Col1-Cre+/– mice show no increase in the hypertrophic chondrocyte (HC) zone of MMP13fl/fl;Col1-Cre+/– mice compared with wild type. (C,D) Picrosirius Red stained femurs from 12-week-old wild-type and MMP13fl/fl;Col1-Cre+/–. MMP13fl/fl;Col1-Cre+/– mice have increased trabecular bone (TB) similar to that observed in the Mmp13–/– mice (SO, secondary site of ossification). Scale bars: 100 µm in A,B; 300 µm in C,D.





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