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Fig. 1. Relationship of Dpr family members. Four Dpr sequences had been published previously, while five others were determined from a combination of the GenBank sequence databases. (A) Neighbor joining phylogenetic analysis of 11 Dpr members reveal two monophyletic groups. Each vertebrate except Xenopus has two paralogous Dpr genes. XDpr1 (XDpr1a) and FRODO (XDpr1b) were found to be a Xenopus specific duplication. Zebrafish Dvl2 was defined as the outgroup. Species are: Hs, Homo sapiens; Mm, Mus musculus; Rn, Rattus norvegicus; Xl, Xenopus laevis; Fr, Fugu rubripes; Dr, Danio rerio. (B) The conserved domains of Dpr family members. The number above the conserved domains is the percent identity and overall similarity (brackets-taking into account conservative changes) from comparison of zebrafish Dpr1 and Dpr2. CD, conserved domain; L2, leucine zipper; P, PDZ binding domain.





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