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Fig. 5. dpr2 morphants phenocopy strabismus/trilobite (stbm) morphants, and functionally interact with stbm and wnt11/silberblick. (A) dpr2 morphants (middle-injected with 7.5 ng dpr2 MO) phenocopy stbm morphants (right-injected with 3 ng). Arrow indicates flattened, non-chevron-shaped somite. Arrowhead indicates narrowed eyes. (B) Scoring of embryos that were co-injected with suboptimal doses of stbm and dpr2 MOs. 0, wild type; 1, moderate CE defects; 2, severe CE defects. (C) Percentage of embryos injected with MOs exhibiting phenotype. (D) Scoring of cyclopia index of embryos co-injected with dpr2 MO and wnt11 MO (a-f). dpr2 MO (normal dose, g,h). 0, wild type; 1, narrowing of the eyes; 2, fusion of the lens. (E) Percentage of embryos injected displaying respective phenotypes. Suboptimal (hypomorphic) dose of dpr2 MO is 3 ng, stbm MO is 0.4 ng and wnt11 MO is 1.5 ng. All injections were balanced with control MO. The numbers in brackets indicate the numbers of embryos used.





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