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Fig. 2. Positional cloning of mau-2. (A) Genetic markers used to map
mau-2. (B) Cosmids and subclones of C09H6 used for rescue assays
(rescuing clones in bold). (C) Genomic structure of mau-2 and the
lesions of the four mau-2 alleles. (D) An alignment of the predicted
amino acid sequence of C. elegans MAU-2 with its homologues from
D. melanogaster (CG4203-PA), F. rubripes
(SINFRUP00000081396), M. musculus (NP_083269) and H. sapiens
(KIAA0892). Identical residues in all five species are shown in dark grey;
identical residues in three or four species are shown in light grey. The
mau-2(qm4) mutation affects the conserved Gly residue (indicated by
an asterisk). The C. elegans protein is about 25% identical to the
vertebrate and the fly proteins. The sequence in the fish is 95% identical to
human MAU-2, and the mouse sequence is more than 99% identical to human
MAU-2.
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