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First published online November 24, 2004

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Ironing out iron uptake in zebrafish

Iron is vital for normal development – its acquisition by red blood cells (RBCs) allows hemaglobin (Hb) production and the delivery of oxygen to developing tissues. However, free iron is toxic to cells and its uptake and transport requires precise regulation. Vertebrate cells mostly obtain iron through transferrin (Tf) receptors, which bind the iron carrier, Tf. Wingert and colleagues now describe three new Tf receptors in zebrafish, Tfr1a, Tfr1b and Tfr2 (see p. 6225). They report that tfr1a mutations cause perturbed Hb production and anemia in the chianti zebrafish mutant, and that tfr1a is specifically required by developing RBCs for iron uptake. By contrast, tfr1b is not required by developing RBCs and probably acquires iron for non-erthyroid tissues instead. Importantly, the authors' findings highlight chianti as the ideal model for studying Tfr1 functions specifically in erythropoiesis, in the absence of other developmental defects.

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Related articles in Development:

The chianti zebrafish mutant provides a model for erythroid-specific disruption of transferrin receptor 1

Rebecca A. Wingert, Alison Brownlie, Jenna L. Galloway, Kimberly Dooley, Paula Fraenkel, Jennifer L. Axe, Alan J. Davidson, Bruce Barut, Laura Noriega, Xiaoming Sheng, Yi Zhou, Tübingen 2000 Screen Consortium, and Leonard I. Zon
Development 2004 131: 6225-6235. [Abstract] [Full Text]  

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Related articles in Development Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Search for Related Content Social Bookmarking                         What's this?