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Fig. 2. Phenotype of MBD1 mutants. (A) Embryo stained with anti-DNA antibody (red). A significant number of mutant embryos appeared rounder and shorter than control embryos. Scale bar: 50 µm. (B) Percentage of embryos with detectable chromosome segregation defects. The data are derived from the microscopical analysis of 200-300 MBD1 mutant (M) and control (C) embryos, respectively. (C) Chromosome segregation defects in MBD1 mutant embryos. Embryos were collected, stained with an antibody against DNA and screened for abnormal mitotic figures. This revealed multiple chromosomal bridges in MBD1 mutants. Scale bar: 5 µm. (D) Eye phenotype of flies carrying a pUAST-lacZ (control) transgene in the wm4h background. (E) The MBD1 mutation results in a strong dominant suppression of the wm4h phenotype. (F) A similar effect was also observed with an independent MBD2/3 mutant allele (see Materials and methods for details).





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