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Fig. 13. Model for the development of early larval and adult neural crest
derivatives. In embryos, neural crest (nc) cells develop into a variety of
derivatives, including early larval glial cells (ELG) and early larval
melanophores (ELM). Some cells are set aside as post-embryonic stem cells or
specified precursors (m) that will be recruited to differentiate during
metamorphosis. During the larval-to-adult transformation, metamorphic glia
(MG) (Parichy et al., 2003)
and metamorphic melanophores (MM) differentiate from latent precursors, with
melanophores passing through a melanoblast intermediate (MB, expressing the
melanophore lineage markers dct and tyr; gray circle).
Additionally some early larval melanophores can transit the metamorphic
boundary and persist into the adult pigment pattern, although relatively few
do so in D. rerio or in most of the other species examined in this
study. In D. nigrofasciatus, there has been a reduction (right red
arrow) in metamorphic melanophores owing to an early block in this lineage,
possibly associated with a puma-dependent pathway; concomitantly,
there has been an increase (left red arrow) in the number of early larval
melanophores persisting into the adult pigment pattern.
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