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Fig. 1. Sequence comparison of Brk from Drosophila melanogaster and from
three other insects, D. pseudoobscura, Anopheles gambiae and
Bombyx mori. The DNA-binding domain (boxed in red) is strongly
conserved in all four species. Outside of the DNA-binding domain there is only
one other region of significant similarity, centered on the Groucho
interaction motif (GiM, blue), although the short CtBP interaction motif (CiM,
blue) is also conserved. The third repression domain, 3R, of D.
melanogaster, identified by functional studies described here, is
outlined in pink. This domain shares some limited sequence identity with
D. pseudoobscura, but this does not extend to the other two species,
although it is rich in Ala and His residues in Anopheles, as well as
in the two Drosophila species.
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