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Fig. 8. Abd-B prevents apoptosis by repressing rpr and grim. (A)
In H99, Abd-Bm double-mutant embryos (dMP2-GAL4, Df(3L)H99,
Abd-BM5/dMP2-GAL4, Df(3L)H99, Abd-BM5; UAS-nls-myc-EGFP) posterior dMP2
and MP1 neurons are generated normally; at stage 16, two dMP2 neurons express
Odd and dMP2-GAL4, whereas two MP1 neurons express Odd only. Abd-B
expression is absent from both neuronal types, and only the posterior tip of
the VNC expresses Abd-Br. (B) In late embryos, neither anterior nor posterior
dMP2 and MP1 neurons undergo apoptosis (100% survival, n=6 VNCs),
indicating that rpr and grim are epistatic to
Abd-B. Insets show two dMP2 and two MP1 neurons in A6, both at stage
16 (left) and at air-filled trachea stages (right). (C) Proposed mechanism of
apoptosis regulation in dMP2 and MP1 neurons. See text for details.
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